"Learning the Science of Cordycepin"

Knowledge I Found On PubMed Central:

Cordycepin, a natural compound in certain fungi like Cordyceps militarist, shows promise in fighting leukemia by interfering with the support system between leukemia cells and mesenchymal stromal cells in the bone marrow. It disrupts the interaction between leukemia cells and mesenchymal stromal cells, hindering leukemia cell support from MSCs. Cordycepin also reduces leukemia stem cell activity, which may impede leukemia growth and improve treatment outcomes. It also targets and reduces the activity of leukemia stem cells, which are known to drive leukemia growth and recurrence. Cordycepin's dual action offers a hopeful therapy approach against leukemia by disrupting critical cell interactions. Overall, cordycepin's effects suggest a promising therapeutic strategy against leukemia by targeting these key cellular interactions.

Antileukemic Cell Proliferation: Cordyceps can slow down or stop the growth of leukemia cells, potentially offering anti-leukemia effects by inhibiting cell growth.

Cytotoxic Activity: Cordyceps can cause cell death in leukemia cells. This cytotoxic effect targets and can kill leukemia cells specifically, which is a common mechanism in anti-cancer therapy.

Cordyceps can hinder leukemia cell growth (antileukemic cell proliferation) and induce cell death in leukemia cells (cytotoxic activity). This highlights the potential of Cordyceps as a natural or complementary treatment for leukemia.

The article discusses a study on how cordycepin from cultivated Cordyceps militaris may boost cell death in human leukemia cells through a combined effect. Cordycepin is a compound in certain fungi that shows potential health benefits, including anti-cancer properties. The research focuses on how this compound affects the programmed cell death process in leukemia cells, offering insights into potential natural therapy/remedy approaches for leukemia.

Here are 6 articles from PubMedCentral, National Library of Medicine, Science Direct and GlennSabin.com that I found to be very intriguing.

Article 1 - Click here "Cordycepin disrupts leukemia association with mesenchymal stromal cells and eliminates leukemia stem cell activity"

Article 2 - Click here "Antileukaemic Cell Proliferation and Cytotoxic Activity of Edible Golden Cordyceps Extracts (Cordyceps militarist)"

Article 3 - Click here "Synergistic property of cordycepin in cultivated Cordyceps militaris-mediated programmed cell death in human leukemia cells"

Article 4 - Click here "Human Trial through the NIH for Natural History Study of CLL/SLL/MBL/LPL/WM and SMZL"

Article 5 - Click here "Research shows caterpillar fungus can slow down growth of cancer cells"

Article 6 - Click here "Cordycepin induces cell cycle arrest and apoptosis by inducing DNA damage and up-regulation of p53 in Leukemia cells"

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"Learning the Science of Cordycepin"

Knowledge I Found On PubMed Central:

Article 7

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