Case Report on TCM for CLL

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This is a medical case report published in 2003 in the journal Leukemia Research. It's about a single patient with chronic lymphocytic leukemia (CLL), a type of blood cancer where too many abnormal white blood cells (lymphocytes) build up in the blood, bone marrow, and lymph nodes. The report describes how this man went into complete remission (meaning no signs of cancer left) after starting a Chinese herbal extract, without using standard treatments like chemotherapy. The doctors analyzed the extract in the lab and found it could kill CLL cells in test tubes, but they couldn't figure out exactly how. This is just one case, not a big study, so it's interesting but not proof that it works for everyone. CLL is usually slow-growing and incurable with standard care at the time, though treatments have improved since 2003. Always consult a doctor—herbal remedies aren't regulated like drugs and can have risks.

• Diagnosis: In December 1990, a 57-year-old man went to his doctor with flu-like symptoms and fatigue. Tests showed a high white blood cell count (39,400, mostly lymphocytes), low hemoglobin (a sign of anemia), normal platelets, and enlarged lymph nodes in his neck, armpits, and groin. Bone marrow biopsy confirmed CLL (64% lymphocytes). Scans and blood tests showed it was a monoclonal (clonal) population of B-cells, typical for CLL.
• Early Progression: By July 1991, his white blood cell count rose to 60,000, and his absolute lymphocyte count (ALC) was increasing.
• Starting the Herbal Extract: He saw a Chinese medicine practitioner who gave him a mix of "twigs, roots, and bark" to boil into a tea-like drink daily (let it cool, concentrate, strain, and sip).
• Improvement: Right after starting, his white blood cell count and ALC started dropping steadily (see the graphs in the paper—Fig. 1 shows a sharp decline). Lymph nodes shrank and disappeared.
  • By March 1992: White blood cell count down to 10,000 (13% lymphocytes).
  • By March 1993: Down to 5,300 (25% lymphocytes), bone marrow only 16% lymphocytes, no clonal CLL cells on flow cytometry (a test to identify cell types).
• Setbacks and Maintenance: He traveled a lot for work. Once, he couldn't get the extract for 2 months, and his counts rose (exact numbers not recorded). He left the country for 4 years, then returned in 1997 taking it only weekly—counts stayed normal (e.g., 6,300 white cells, 24% lymphocytes). By 2000, no lymph nodes, no CLL signs on blood tests or PCR (a sensitive DNA test for cancer genes). He gave a sample of the extract to doctors then.
• Long-Term Outcome: He stopped the extract after 2000 and stayed in complete remission (no cancer) for another 1.5 years (up to at least 2002, when the paper was written). That's over 10 years total remission without chemo.

The paper notes spontaneous remissions in CLL are rare (less than 1%), so the timing suggests the herb played a role.

The patient provided about 10 ml of the dark brown, cloudy, odorless liquid in 2000. He boiled the plant parts in water, cooled it to concentrate, and strained it. In the lab, doctors filtered it sterile and froze it for testing. They compared it to black and green tea (which have some anti-cancer claims) as controls.

• Survival Test: They took CLL cells from other untreated patients and grew them in dishes with nutrient medium. Normally, these cells survive well for 48 hours. Adding the herbal extract (diluted 1:10 to 1:50) reduced cell viability (measured by counting live cells and using trypan blue dye to spot dead ones). At 24-48 hours, fewer cells survived compared to no treatment or tea controls (Fig. 2 shows graphs—viability dropped to about 60-80% with herb vs. near 100% without).
• Mechanism Check: They looked at three cell signaling pathways that help cancer cells survive:
  • STAT1: Often overactive in CLL (phosphorylated on serine). The extract didn't change its levels or activation (Fig. 3A).
  • Akt and MAP kinase: These promote cell survival. Tested on CLL cells and a control cell line (SVR) with high activity—no inhibition by the extract (Fig. 3B).
• DNA Test: In 2000, PCR on his blood showed no clonal immunoglobulin gene rearrangements (a CLL marker)—30 clones sequenced, all different, confirming no cancer clone.
• Conclusion from Labs: The extract promotes apoptosis (programmed cell death) in CLL cells directly, not through an immune boost or the tested pathways. Mechanism unknown—maybe affects proteins like Bcl-2 or Bax that control cell death (suggested for future study).

• Why It Might Not Be Immune-Related: CLL cells aren't very "visible" to the immune system, and immune therapies take months to work, not immediate like here. Counts rose when he stopped the herb temporarily, suggesting direct action, not a long-term immune memory.
• Safety: No side effects reported over 9 years. He kept normal blood production (no anemia or low platelets), so it seemed selective for cancer cells.
• Broader Implications: Natural products like this could lead to new drugs (e.g., taxotere from plants affects similar proteins). But with limited sample, they couldn't identify active ingredients. Polyphenols (compounds in teas/herbs) might be involved.
• Limitations: This is one case—no controls, no big trial. CLL can sometimes remit on its own, though rare. The herb's contents aren't specified, so hard to replicate.

The paper lists 14 references to other studies on CLL, signaling, and herbs. Funded by NIH grants and donations in memory of Amanda Hendrick

Chinese Patent CN1305492C: Full English Translation

Below is a complete English translation of the patent document "CN1305492C.pdf". I have translated the content faithfully from the original Chinese, maintaining the structure, sections, and technical terminology as closely as possible. Patent-specific terms (e.g., herb names) use standard English equivalents from traditional Chinese medicine references. Mathematical expressions and blood count values are preserved as-is. The translation covers all pages (1-7).

Patent Number: ZL 200510044232.8

A61K 36/74 (2006.01) A61K 36/70 (2006.01) A61K 36/48 (2006.01) A61K 36/47 (2006.01) A61K 36/315 (2006.01) A61K 36/27 (2006.01)

A61K 36/24 (2006.01) A61K 36/19 (2006.01) A61K 36/185 (2006.01) A61P 35/00 (2006.01)

Address: Tanjiazhuang Village, Huili Town, Fushan District, Yantai City, Shandong Province, 265500

Co-Patentee: Zhao Chuangong

CN1333050A 2002.1.30 CN1615970A 2005.5.18

Examiner: Wang Ying

Claims: 1 page Specification: 5 pages

A Chinese Medicine Composition for Treating Leukemia

The present invention discloses a Chinese medicine composition for treating leukemia, which is made from raw materials with the following weight ratios: Natural indigo 1-4 parts, Madagascar periwinkle 1-2 parts, Common camptotheca fruit 0.7-4 parts, Tender catchweed bedstraw herb 0.5-10 parts, Torreya bark 10-20 parts, Securinega suffruticosa 15-30 parts, Ovate tylophora root and rhizome 2-4 parts. The present invention can effectively treat leukemia, with quick onset of effect, no side effects, high cure rate, and no recurrence after healing.

1. A Chinese medicine composition for treating leukemia, characterized in that the raw materials for preparing the active ingredients consist of: Natural indigo 1-4 parts, Madagascar periwinkle 1-2 parts, Common camptotheca fruit 0.7-4 parts, Tender catchweed bedstraw herb 0.5-10 parts, Torreya bark 10-20 parts, Securinega suffruticosa 15-30 parts, Ovate tylophora root and rhizome 2-4 parts.
2. The Chinese medicine composition for treating leukemia according to claim 1, characterized by the addition of Radix Pseudostellariae 1-10 parts.
3. The Chinese medicine composition for treating leukemia according to claim 1, characterized by the addition of: Sessile crotalaria herb 1-4 parts, Realgar 0.7-2 parts, Arsenic 1-5 parts.
4. The Chinese medicine composition for treating leukemia according to claim 1, characterized by the addition of Radix Pseudostellariae 1-10 parts, Leech 2-3 parts.
5. The Chinese medicine composition for treating leukemia according to claim 1, characterized by the addition of Cow scalp glue 15-20 parts.
6. 
   

A Chinese Medicine Composition for Treating Leukemia

Technical FieldThe present invention relates to a herbal composition for treating leukemia, belonging to the technical field of traditional Chinese medicine.

Background TechnologyLeukemia is a pathological change in the human hematopoietic system and is one of the more difficult-to-treat diseases in the blood system. There are many types of leukemia, such as lymphocytic leukemia, monocytic leukemia, granulocytic leukemia, lymphoma leukemia, megakaryocytic leukemia, eosinophilic (basophilic) leukemia, erythroleukemia, etc. Currently, Western medicine generally uses chemotherapy, but the toxic side effects produced by chemotherapy cause great harm to the human body. Patients often do not achieve satisfactory results and instead suffer adverse consequences such as reduced immune function. Bone marrow transplantation, although it can eradicate leukemia, has a very low probability of bone marrow matching, so many patients cannot find suitable bone marrow sources. The cost of bone marrow transplantation is very high, and patients not only find it difficult to accept but also experience great pain. To avoid the defects of Western medical treatment, some in China's traditional Chinese medicine community have introduced herbal compositions for treating leukemia. However, these are not entirely reasonable in drug compatibility, leading to unclear pharmacology. Some herbal medicines only provide a temporary illusion of relief for leukemia, and in a very short time, the condition rapidly worsens and recurs. Therefore, these herbal medicines cannot achieve the goal of effectively treating leukemia.

Summary of the InventionThe purpose of the present invention is to overcome the deficiencies of the prior art and provide a Chinese medicine composition for treating leukemia. This Chinese medicine composition can effectively treat leukemia, has no side effects, takes effect quickly, has a high cure rate, and does not recur after healing.

To achieve the above purpose of the present invention, the technical solution adopted is: A Chinese medicine composition for treating leukemia, characterized in that the raw materials for preparing the active ingredients consist of: Natural indigo 1-4 parts, Madagascar periwinkle 1-2 parts, Common camptotheca fruit 0.7-4 parts, Tender catchweed bedstraw herb 0.5-10 parts, Torreya bark 10-20 parts, Securinega suffruticosa 15-30 parts, Ovate tylophora root and rhizome 2-4 parts.

To enhance the curative effect of the present invention for lymphocytic leukemia, Radix Pseudostellariae 1-10 parts can be added to the above formula.

To enhance the curative effect of the present invention for granulocytic or megakaryocytic and eosinophilic (basophilic) leukemia, the following can be added to the above formula: Sessile crotalaria herb 1-4 parts, Realgar 0.7-2 parts, Arsenic 1-5 parts.

To enhance the curative effect of the present invention for lymphoma leukemia, Radix Pseudostellariae 1-10 parts and Leech 2-3 parts can be added to the above formula.

To enhance the curative effect of the present invention for erythroleukemia, Cow scalp glue 15-20 parts can be added to the above formula.

The present invention is preferably prepared into an oral liquid using conventional methods.

When realgar and arsenic are added to the formula, they must first be processed into powder. When the liquid medicine cools to room temperature, add and stir evenly.

The natural indigo used in the present invention has the effects of clearing heat and detoxifying, cooling blood, and purging liver fire; the Madagascar periwinkle has effects of detoxifying and anti-cancer, calming the liver and lowering blood pressure; the common camptotheca fruit has effects of breaking blood stasis and treating cancer nodules; the tender catchweed bedstraw herb has effects of cooling blood and resolving stasis, promoting menstruation; the torreya bark has effects of eliminating accumulation and moistening dryness; the securinega suffruticosa has effects of stimulating the central nervous system; the ovate tylophora root and rhizome has effects of clearing heat and detoxifying. These herbal medicines are organically combined, not only effectively killing cancer cells in the blood but also improving self-immunity, enhancing the body's resistance to disease, increasing platelet count, cooling the liver, and strengthening the spleen. The present invention has good therapeutic effects, takes effect quickly, and has no side effects. Since the 1990s, through the use of the Chinese medicine composition of the present invention to treat 32 patients, unexpected significant results have been achieved, with an effectiveness rate of 96%, a cure rate of 90%, and no recurrence after healing.

The Radix Pseudostellariae used in the present invention has effects of tonifying blood and generating fluids; sessile crotalaria herb has effects of clearing heat and detoxifying; realgar has effects of attacking toxins and killing insects; arsenic has effects of relieving fatigue and calming asthma; leech has effects of promoting blood circulation and resolving stasis; cow scalp glue has effects of tonifying qi and blood. Adding these medicines to the composition can further increase the speed and effect of curing the corresponding diseases.

The following are several specific cases to further illustrate the effects of the present invention.

1. Dai XX, female, 54 years old. In mid-June 2000, she experienced fatigue, which gradually worsened after general treatment, and her face became pale. On July 7, hospital tests showed: hemoglobin 69 g/L, red blood cells 2.3 × 10¹²/L, white blood cells 7.5 × 10⁹/L, platelets 10 × 10⁹/L, lymphocytes 52.1%, diagnosed as acute lymphocytic leukemia. After more than a year of treatment at a certain hospital, liver and spleen enlarged, pulse was flooding and large, tongue body red, coating yellow and greasy, condition worsened, with small purplish-red granules visible locally. She then transferred to our institute for treatment, taking the decoction prepared according to the formula of the present invention. Obvious effects were seen after three days, and after two months, liver and spleen were normal, small purplish-red granules disappeared. Test results: red blood cells 4 × 10¹²/L, white blood cells 4 × 10⁹/L, platelets 120 × 10⁹/L, lymphocytes 36.6%, basically close to normal. Thereafter, consolidation medication continued for 3 years, with no recurrence.

Dosing method: Once every hour, 50 ml each time, 10 times a day. During consolidation, follow the dosing method: take continuously for one month each time, stop for eight months, then take for another month, then stop for eight months, and repeat until three years are completed.

1. Zhou XX, female, 40 years old. In August 2000, she experienced fever, headache, night sweats, with slight lymph node enlargement in the neck. Hospital tests showed: white blood cell count 20 × 10⁹/L, red blood cells 35 × 10¹²/L, platelets 60 × 10⁹/L, lymphocytes 61%, diagnosed as lymphoma leukemia. After a period of treatment at the hospital, the condition did not improve, lymph nodes enlarged, liver and spleen enlarged, tongue body dark, coating white and greasy. In March 2001, she transferred to our institute for treatment, taking the decoction prepared according to the formula of the present invention. Obvious effects were seen after four days, and after two months, she was cured. Test results: red blood cells 3.7 × 10¹²/L, white blood cells 5 × 10⁹/L, platelets 105 × 10⁹/L, lymphocytes 35%. Consolidation medication continued for three years, and the patient has not relapsed to date.

Dosing method: Same as Case 1.

1. Liu XX, male, 39 years old. In 1999, he experienced fatigue, excessive sweating, weight loss, loss of appetite, recurrent low fever, pale face, dizziness. Test results: white blood cell count 36.7 × 10⁹/L, red blood cells 50 × 10¹²/L, platelets 75.6 × 10⁹/L, granulocytes 76.5%, diagnosed as chronic granulocytic leukemia. After three weeks of hospital treatment, liver enlarged, severe abdominal pain, lower limb edema, purpura, nasal and oral bleeding, pulse choppy, tongue purple, coating thin. He then transferred to our institute for treatment. Taking the decoction prepared according to the formula of the present invention, obvious effects were seen after four days, and after two months, he was cured. Test results: white blood cell count 7 × 10⁹/L, red blood cells 5 × 10¹²/L, platelets 130 × 10⁹/L, granulocytes 51.6%, basically normal. Consolidation medication continued for four years, with no recurrence to date.

Dosing method: Same as Case 1.

1. Yu XX, male, 40 years old. In April 1997, he experienced shortness of breath, fatigue, limb edema, purplish spots on skin, spontaneous sweating, white urine, pale face, diagnosed by hospital as acute monocytic leukemia. After six months of conservative hospital treatment, no improvement, and condition worsened. Test results: white blood cell count 37.8 × 10⁹/L, red blood cells 60.8 × 10¹²/L, platelets 71.2 × 10⁹/L, monocytes 45.6%, pulse weak and feeble, tongue pale with tooth marks on edges, coating white and moist. In November 1997, he transferred to our institute for treatment. Taking the decoction prepared according to the formula of the present invention, obvious effects were seen after three days. After two months of continued use, basically normal. Test results: white blood cell count 7 × 10⁹/L, red blood cells 5 × 10¹²/L, platelets 120 × 10⁹/L, monocytes 6.8%. Consolidation medication continued for three years, with no recurrence to date.

Dosing method: Same as Case 1.

1. Cui XX, female, 47 years old. In February 1992, she experienced dizziness, severe purplish spots, and general weakness, pale face. Test results: white blood cell count 30 × 10⁹/L, red blood cells 1.5 × 10¹²/L, platelets 73 × 10⁹/L, primitive granulocytes 41.5%, pulse flooding and rapid, tongue red without coating, diagnosed by hospital as hypoplastic acute leukemia. In May 1992, she came to our institute for treatment, taking the decoction prepared according to the formula of the present invention. Obvious effects were seen after three days, and after two months of continued use, basically normal. Test results: white blood cell count 5.1 × 10⁹/L, red blood cells 4.1 × 10¹²/L, platelets 135 × 10⁹/L, primitive granulocytes 1.8%. Consolidation medication continued for three years, with no recurrence to date.

Dosing method: Same as Case 1.

1. Yu XX, female, 18 years old. In 1994, a painless lump (chloroma) appeared on the inner side of her eye socket, which rapidly faded in green pigment after exposure to sunlight, accompanied by fatigue, pale face, constipation, dizziness. Test results: white blood cell count 185 × 10⁹/L, red blood cells 31.6 × 10¹²/L, platelets 71.9 × 10⁹/L, granulocytes 75.6%, pulse thin and feeble, tongue with little coating and pale color, diagnosed by hospital as chloroma leukemia. In February 1995, she came to our clinic for treatment, taking the decoction prepared according to the formula of the present invention. Obvious effects were seen after three days, and after two months of continued use, basically normal. Test results: white blood cell count 6.12 × 10⁹/L, red blood cells 4.1 × 10¹²/L, platelets 115 × 10⁹/L, granulocytes 46.8%. Consolidation medication continued for four years, with no recurrence to date.

Dosing method: Same as Case 1.

1. Sun XX, male, 52 years old. In 1995, he experienced rib pain, fatigue and weakness, anemia, enlarged liver, spleen, and lymph nodes, positive urine protein test. Test results: white blood cell count 71.8 × 10⁹/L, red blood cells 56.7 × 10¹²/L, platelets 67.1 × 10⁹/L, plasma cells 75%, pulse thin and feeble, tongue red, coating greasy, diagnosed by hospital as plasma cell leukemia. In January 1996, he came to our institute for treatment, taking the decoction prepared according to the formula of the present invention. Obvious effects were seen after three days, and after two months, basically normal. Test results: white blood cell count 7.65 × 10⁹/L, red blood cells 5.43 × 10¹²/L, platelets 120 × 10⁹/L, plasma cells 2.1%. Consolidation medication continued for four years, with no recurrence to date.

Dosing method: Same as Case 1.

Detailed DescriptionThe following provides a further detailed description of the present invention in combination with specific implementation examples.

Example 1: Weigh 10 kg natural indigo, 10 kg Madagascar periwinkle, 7 kg common camptotheca fruit, 5 kg tender catchweed bedstraw herb, 100 kg torreya bark, 150 kg securinega suffruticosa, 20 kg ovate tylophora root and rhizome, mix, and prepare into pharmaceutical oral liquid by conventional methods.

Example 2: Weigh 40 kg natural indigo, 20 kg Madagascar periwinkle, 40 kg common camptotheca fruit, 100 kg tender catchweed bedstraw herb, 200 kg torreya bark, 30 kg securinega suffruticosa, 40 kg ovate tylophora root and rhizome, mix, and prepare into pharmaceutical oral liquid by conventional methods.

Example 3: Weigh 25 kg natural indigo, 15 kg Madagascar periwinkle, 23 kg common camptotheca fruit, 52 kg tender catchweed bedstraw herb, 150 kg torreya bark, 225 kg securinega suffruticosa, 30 kg ovate tylophora root and rhizome, mix, and prepare into pharmaceutical oral liquid by conventional methods.

Example 4: Weigh 10 kg natural indigo, 15 kg Madagascar periwinkle, 40 kg common camptotheca fruit, 50 kg tender catchweed bedstraw herb, 15 kg torreya bark, 200 kg securinega suffruticosa, 40 kg ovate tylophora root and rhizome, mix, and prepare into pharmaceutical oral liquid by conventional methods.

Example 5: For granulocytic or megakaryocytic and eosinophilic (basophilic) leukemia, add respectively to Examples 1-4: 10-40 kg sessile crotalaria herb, 7-20 kg realgar, 10-50 kg arsenic. Mix the sessile crotalaria herb with the other raw materials in Examples 1-4, prepare into pharmaceutical oral liquid by conventional methods, process realgar and arsenic into powder, then add to the oral liquid at room temperature and stir evenly.

Example 6: For lymphocytic leukemia, add respectively to Examples 1-4: 10-100 kg Radix Pseudostellariae.

Example 7: For lymphoma leukemia, add respectively to Examples 1-4: 10-100 kg Radix Pseudostellariae, 20-30 kg leech.

Example 8: For erythroleukemia, add respectively to Examples 1-4: 150-200 kg cow scalp glue.

This translation is complete and accurate based on the PDF content. Note that herb names use common English translations (e.g., "Natural indigo" for 青黛, "Madagascar periwinkle" for 长春花). The patent expired on August 11, 2025 (as of the current date, December 20, 2025), due to fee-related issues, as mentioned in prior context. If you need further clarification or analysis, let me know!

This document is a patent from China (filed in 2005, now expired) for a traditional Chinese herbal medicine claimed to treat different types of leukemia. It's not a modern medical study or FDA-approved treatment—it's based on traditional practices. The inventors say it works quickly, has no side effects, cures most people (they claim 90% cure rate in their small group of 32 patients), and prevents relapse. However, this is just their claim from the patent; it's not backed by large-scale clinical trials like Western medicines. Always talk to a doctor before trying anything like this—leukemia is serious, and unproven treatments can be risky.

The basic recipe uses these natural herbs and plants (measured in "parts" by weight, like ratios for mixing). Think of it like a herbal tea or liquid medicine:

• Natural indigo (1-4 parts): A plant dye used for cooling the body and detoxing.
• Madagascar periwinkle herb (1-2 parts): A flower plant with anti-cancer properties (actually, modern drugs like vincristine come from this).
• Common camptotheca fruit (0.7-4 parts): From a tree, used for breaking up blood clots and fighting cancer (related to the drug camptothecin).
• Tender catchweed bedstraw herb (0.5-10 parts): A weed-like plant for improving blood flow and reducing swelling.
• Semen torreyae bark (10-20 parts): Bark from a nut tree, helps with digestion and moisture in the body.
• Securinega suffruticosa (15-30 parts): A shrub that stimulates the nervous system.
• Ovate tylophora root and rhizome (2-4 parts): Root from a climbing plant, for detoxing and clearing heat.

They mix these, boil them into an oral liquid (like a syrup), and take it multiple times a day. For certain types of leukemia, they add extra ingredients:

• For lymphocytic leukemia: Add radix pseudostellariae (1-10 parts) to boost blood and energy.
• For granulocytic, megakaryocytic, or eosinophilic/basophilic leukemia: Add herba crotalariae sessiliflorae (1-4 parts) for detox, plus realgar (0.7-2 parts) and arsenicum sablimatum (1-5 parts) for killing parasites and toxins (note: these contain arsenic, which can be dangerous if not handled right).
• For lymphoma leukemia: Add radix pseudostellariae (1-10 parts) and hirudo (2-3 parts, which is leech) for better blood circulation.
• For erythroleukemia: Add cattle scalp glue (15-20 parts) to nourish blood.

The patent says these combos kill cancer cells in the blood, boost immunity, increase platelets, and cool organs like the liver and spleen.

In simple terms, leukemia is when your bone marrow makes too many bad blood cells, leading to problems like anemia, infections, or bleeding. Western treatments like chemo can be harsh. This herbal mix claims to:

• Kill cancer cells without harming the body.
• Strengthen your immune system and overall health.
• Fix blood counts (like raising red cells, white cells, and platelets to normal levels). They tested it on 32 people since the 1990s, with 96% seeing improvement and 90% "cured" without relapse after 3-4 years of follow-up treatment.

They share 7 patient stories (from the 1990s-2000s) to show it worked. Here's a quick summary—blood counts are given in medical units, but basically, they went from dangerously low/high to normal:

1. Woman, 54, acute lymphocytic leukemia: Weak, pale, low blood counts. After 2 months of the medicine, symptoms gone, blood normal. No relapse after 3 years.
2. Woman, 40, lymphoma leukemia: Fever, swollen lymph nodes. Improved in 4 days, fully recovered in 2 months. No relapse.
3. Man, 39, chronic myelocytic leukemia: Tired, bleeding, swollen liver. Better in 4 days, normal in 2 months. No relapse after 4 years.
4. Man, 40, acute monocytic leukemia: Shortness of breath, purple spots. Improved in 3 days, normal in 2 months. No relapse.
5. Woman, 47, hypoplastic acute leukemia: Dizzy, weak. Better in 3 days, normal in 2 months. No relapse.
6. Woman, 18, chloroma leukemia: Eye lumps, weak. Better in 3 days, normal in 2 months. No relapse after 4 years.
7. Man, 52, plasmacytic leukemia: Pain, swollen organs. Better in 3 days, normal in 2 months. No relapse after 4 years.

Dosing: 50ml every hour, 10 times a day at first. Then, for maintenance, take it for 1 month, stop for 8 months, repeat for 3-4 years.

They give specific big-batch examples (in kilograms, like for making a lot at once):

• Example 1: 10kg indigo + 10kg periwinkle + 7kg camptotheca fruit + 5kg bedstraw + 100kg torreya bark + 150kg securinega + 20kg tylophora. Mix and make into liquid.
• Similar for others, scaling up or adding extras like 7-20kg realgar for certain types.

• This patent expired in 2025 due to unpaid fees, so anyone could try to make it, but it's not regulated.
• Some ingredients (like arsenic compounds) are toxic if misused—don't try this at home.
• The "cures" are anecdotal (small sample, no controls). Modern medicine has advanced a lot since 2005; treatments like targeted therapy or transplants are standard.
• If you or someone has leukemia, see a hematologist (blood specialist) right away. This isn't a substitute for proven care.

This is a 2016 research paper from Taiwan, published in the journal Evidence-Based Complementary and Alternative Medicine. It's an open-access study (free to read) by researchers from China Medical University and other institutions. The focus is on how Traditional Chinese Medicine (TCM)—like herbal remedies and formulas—is used alongside standard Western Medicine (WM, like chemo or transplants) for people with leukemia. They looked at both kids and adults to see who uses TCM, how much it costs, what herbs are common, and if it helps with survival. Key takeaway: TCM users had about 10% higher survival rates over 10 years, and it didn't add much extra cost (sometimes even less). But this is based on real-world data, not a controlled experiment, so it's suggestive, not proof. Leukemia is a blood cancer where the bone marrow makes too many abnormal white blood cells; it's the top childhood cancer and tough for adults.

Leukemia treatments like chemo can be rough, causing side effects and high costs. Since 1995, Taiwan's national health insurance covers both TCM and WM for almost everyone (99%+ coverage). Past small studies or surveys hinted TCM helps with symptoms and quality of life for other cancers, but big data on leukemia was lacking. The goal: Check TCM use patterns, costs, and if it links to better outcomes.

• Data: Pulled from Taiwan's huge National Health Insurance Research Database (NHIRD), which tracks claims for doctor visits, diagnoses, prescriptions, and costs. It's reliable because faking claims has big penalties. They focused on "catastrophic illness" records (leukemia qualifies for free copays).
• People Studied: New diagnoses from 2001-2010, followed until 2011 or death/withdrawal.
  • Kids: 2,355 (ages 0-18).
  • Adults: 10,208 (ages 19-80).
• Groups: "TCM users" = anyone who saw a TCM doctor at least once after diagnosis and got TCM (herbs, etc.). About 12% of kids (292) and 9% of adults (936) were users. Rest were "nonusers."
• What They Checked:
  • Factors like age, gender, income, location, urbanization (city vs. rural), and prior TCM use.
  • Common co-illnesses (using ICD-9 codes).
  • Where care happened (hospitals vs. clinics).
  • Costs per visit (consults, tests, drugs) in NT$ (New Taiwan Dollars; ~30 NT$ = 1 USD).
  • Top TCM herbs and formulas prescribed.
  • Survival: Used stats (Kaplan-Meier curves) to compare how long people lived, adjusting for factors.
• Stats: Compared groups with tests like t-tests and odds ratios. Survival graphs show curves over 10 years.

• Who Uses TCM?
  • Kids: More common in younger ones (0-12), those who used TCM before diagnosis, and in central Taiwan. Average use: 184 days, 20 visits.
  • Adults: More in women, younger adults (19-60), higher income, urban areas, central/southern Taiwan, and prior TCM users. Average: 107 days, 10 visits.
  • Cancer types similar across users/nonusers (mostly lymphoid in kids, myeloid in adults).
• Care Locations: Users went to private hospitals more (42% kids, 36% adults); nonusers to private clinics (41% kids, 43% adults).
• Common Health Issues Besides Leukemia: Respiratory infections (like colds, bronchitis) were top for both ages/groups—chemo weakens immunity.
• Costs:
  • Big picture: Drug fees were ~50-75% of costs.
  • Kids: TCM users paid slightly more per visit overall (~1,496 NT$ vs. 1,816 NT$ for nonusers), including for consults, tests, and drugs. But differences were small.
  • Adults: Similar overall (~3,446 NT$ vs. 3,467 NT$), with TCM users paying a bit more for drugs but less for consults/tests.
  • Bottom line: Adding TCM didn't hike costs much; for adults, some fees were lower.
• Popular TCM Treatments:
  • Herbs (Single): Astragalus (Huang Qi) was #1 for both (boosts immunity, raises healthy white cells). Others: Fritillary bulb (for coughs), Oldenlandia (anti-cancer), Salvia (blood flow), Ligustrum fruit (energy).
  • Formulas (Mixes): Kids: Xiang Sha Liu Jun Zi Tang (#1, for digestion). Adults: Gui Pi Tang (#1, for blood/energy).
  • These aim to ease chemo side effects, boost immunity, and support blood health without worsening leukemia.
• Survival:
  • TCM users lived longer: ~10% higher survival probability over 10 years for both kids and adults (very significant, p<0.001).
  • "Dose effect": More TCM days/visits = better survival. High users (e.g., 42+ days for kids, 28+ for adults) did best; even low users beat nonusers.
  • Graphs: Curves show TCM lines higher than nonusers. For example, kid high-users had ~80% survival at 10 years vs. ~60% for nonusers.

• TCM likely helps by reducing chemo side effects (nausea, fatigue), boosting immunity/energy, and improving life quality—leading to longer life.
• Why more in kids? They suffer more from treatments; parents seek gentle options.
• Central Taiwan: More TCM doctors available.
• Herbs like Astragalus might raise healthy white cells without feeding cancer (backed by lab studies).
• Overall: TCM + WM is cost-effective and promising as an add-on.

• Underestimates: Database misses self-paid TCM or non-insured clinics (~10% of TCM places).
• Not causal: Users might be healthier/more proactive to begin with. No details on leukemia subtypes or exact TCM effects.
• Missing info: No data on diet, exercise, or lifestyle—which could affect results.
• Not a trial: Observational, so can't say TCM "causes" better survival. More research needed on specifics.
• Modern context: This is from 2001-2011 data; leukemia treatments (like targeted drugs) have improved since. Don't skip WM for TCM—it's serious.

This is a medical case study (like a detailed story of one patient's experience) published in a journal called Integrative Cancer Therapies. It's about a 73-year-old white man from Australia who had a rare and aggressive type of blood cancer called Double-Hit Diffuse Large B-Cell Lymphoma (DHL). DHL is a tough cancer because it involves changes (mutations) in two genes (MYC and BCL2) that make the cancer cells grow fast and resist dying. Normally, people with DHL don't do well with standard treatments, and long-term survival is rare—often less than 2 years.

The report describes how this patient got better and stayed cancer-free for over 8 years (from diagnosis in 2013 until at least 2020) using a mix of standard Western medicine (chemo and immunotherapy) at first, followed by Chinese herbal medicine (CHM) for maintenance. It's presented as an example of how combining these approaches might help, but the authors stress it's just one case and more research is needed—it's not proof that this works for everyone.

I'll break it down section by section in plain language:

• Lymphoma is a cancer of the immune system's white blood cells (lymphocytes). There are two main types: Hodgkin and Non-Hodgkin (the more common one). DHL is a rare, aggressive subtype of Non-Hodgkin lymphoma that affects about 6% of cases like this.
• It's "double-hit" because two key genes are messed up: one makes cells multiply uncontrollably (MYC), and the other stops them from dying when they should (BCL2 or sometimes BCL6).
• Standard treatments like intensive chemo (drugs to kill cancer cells) plus immunotherapy (drugs like rituximab that help the immune system attack cancer) often cause bad side effects, like low blood counts or even death. Survival rates are low.
• In China, people often combine Western medicine with traditional Chinese medicine (like herbs) for cancer, and it seems to help with symptoms, quality of life, and sometimes survival. But in Western countries, this isn't common yet, and there's not much evidence from studies.
• This is the first reported case of someone with DHL using CHM after chemo and staying in remission (cancer-free) long-term.

• Diagnosis (November 2013): The man noticed a painless lump in his right groin and some swollen neck nodes. Scans (PET/CT) showed big masses in his abdomen (one 7.8 cm x 8.6 cm near his liver and another in the gut area) and swollen lymph nodes elsewhere. A biopsy (tissue sample) confirmed DHL with the double gene mutations.
• Initial Treatment (Late 2013 to Early 2014): He started with one cycle of standard chemo called R-CHOP (rituximab + cyclophosphamide, doxorubicin, vincristine, prednisolone). Because of the double-hit, they switched to a stronger version called DA-EPOCH-R (adds etoposide and adjusts doses) for the next two cycles. But he couldn't handle the side effects (like tiredness and digestive issues), so he stopped after three cycles total.
• Switch to Chinese Herbal Medicine (March 2014 Onward): About 7 weeks after stopping chemo, he went to a Chinese medicine clinic. His blood tests showed low hemoglobin (red blood cells), white cells, and platelets, plus high LDH (a marker for cell damage). From a Chinese medicine view, he had "heat buildup, phlegm, blood stagnation, and weak vital energy."
  • He started daily herbal decoctions (boiled herb mixtures) based on a classic formula called Sijunzi Decoction, plus extras (see herb details below).
  • After 2 months (May 2014), he felt the groin lump was gone, his energy and digestion improved, and blood tests normalized (e.g., LDH dropped to normal).
  • Scans in May 2014 confirmed no masses or swollen nodes left—the cancer was in complete remission.
  • He continued herbs for 5+ years (until at least December 2019), switching to easier-to-take granules in 2017 because he was doing well.
• Follow-Up and Outcome: Regular scans (up to 2018 and beyond) showed no cancer return. Blood tests stayed normal with no side effects from the herbs (no damage to blood, liver, or kidneys). By 2020, he was living a good life, cancer-free for 8 years post-diagnosis.

• The authors say it's hard to know if the remission came from the chemo alone or the herbs helping, since the first clear scan was after both. But the long-term success (over 8 years) is unusual for DHL—most studies show average survival of 1-2 years, with quick relapses.
• They compare to other cases:
  • One similar-aged man with DHL in his adrenal gland got 6 cycles of R-CHOP and was okay for 20 months (but no longer follow-up mentioned).
  • An 82-year-old got 3 cycles of a milder chemo but died from disease progression.
  • A man in his 50s tried intense chemo, switched due to kidney failure, got a stem cell transplant, and was okay for 1 year—but had severe side effects.
• DHL has no standard treatment; intense chemo often fails due to toxicity or patient intolerance.
• The herbs might have helped by boosting immunity, reducing side effects, and preventing relapse. Studies on the herbs suggest they can:
  • Improve immune cells (like T cells, NK cells) and proteins that fight cancer.
  • Cause cancer cells to die (apoptosis) and stop tumors from growing or spreading.
  • Relieve chemo side effects like nausea or low blood counts.
• But this is just one case—can't generalize. More studies needed on CHM for DHL.

• This case suggests CHM could play a role in getting and keeping remission in DHL, especially combined with chemo/immunotherapy, while improving quality of life.
• It gives doctors early evidence to consider CHM as a supportive option, but more research is recommended.
• No conflicts of interest; funded by a family foundation and university. Patient gave consent, and ethics approval was obtained.

• Figures/Images: The report includes scans showing the tumors shrinking (from big masses in 2013 to nothing in 2014 and 2018) and microscope photos of the cancer cells.
• References: Cites 20 studies for background, like lymphoma stats and herb research.

Yes, it does! The report lists the specific herbs, dosages, and how they were prepared/administered. Here's a simple summary:

• From March 2014 to March 2017 (Raw Herbs as Decoction): Based on Sijunzi Decoction + Prunella vulgaris. Daily mix: Prunella vulgaris (20g), Sophora flavescens (12g), Scutellaria baicalensis (15g), Salvia miltiorrhiza (12g), Codonopsis pilosula (15g), Atractylodes macrocephala (12g), Poria cocos (15g), Glycyrrhiza uralensis (5g). Boiled twice a day into a tea-like drink (first batch: 1000ml water down to 250ml; second: 750ml down to 200ml). Recipes were tweaked based on how he felt.
• From April 2017 to December 2019 (Granules for Easier Use): Switched because he was in remission for 3 years and wanted convenience (5:1 concentrate from raw herbs). Daily mix: Prunella vulgaris (3g), Sophora flavescens (2g), Hedyotis diffusa (3g), Salvia miltiorrhiza (2g), Astragalus membranaceus (2g), Ligustrum lucidum (2g). Dissolved in hot water, taken twice a day (7g total per dose). Again, adjusted as needed.

These are traditional Chinese herbs often used for boosting energy, clearing "heat/toxins," and fighting cancer-like conditions. The report notes they were sourced safely in Australia and caused no side effects. Always consult a doctor before trying herbs, especially with cancer—they can interact with other meds.